MOLECULAR DISPLAY ON MULTIMERIC PROTEIN SCAFFOLDS DERIVED FROM THE E2 COMPONENT OF THE ALPHA-KETOACID DEHYDROGENASE

摘要

Peptides or polypeptides are displayed using multienzyme complex proteins, especially an E2 protein of a 2-oxo acid dehydrogenase multienzyme complex. Such display is useful in screening for peptides or polypeptides which bind target proteins of interest or are bound by target antibodies of interest, or which have other desirable properties, and in the elicitation of immune responses, e.g. for vaccination. A variety of different numbers of peptides or polypeptides can be displayed on a single complex, and a variety of different peptides or polypeptides can be displayed on the same complex.