发明名称 |
CARBOXYLIC ACID DERIVATIVES AS IP ANTAGONISTS |
摘要 |
This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula (I) wherein R<1>, R<2>, and R<3> are each independently in each occurrence aryl or heteroaryl, R<4> is -COOH or tetrazolyl, A, B, m, n, and r are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, processes for their preparation and their use as therapeutic agents.
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申请公布号 |
WO0168591(A1) |
申请公布日期 |
2001.09.20 |
申请号 |
WO2001EP02597 |
申请日期 |
2001.03.08 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
COURNOYER, RICHARD, LEO;KEITZ, PAUL, FRANCIS;LOWRIE, LEE, EDWIN, JR.;MUEHLDORF, ALEXANDER, VICTOR;O'YANG, COUNDE;YASUDA, DENNIS, MITSUGU |
分类号 |
A61K31/198;A61K31/341;A61K31/343;A61K31/36;A61K31/381;A61K31/405;A61K31/4184;A61K31/423;A61K31/443;A61K31/47;A61K31/497;A61K31/501;A61K31/506;A61P1/00;A61P1/02;A61P7/10;A61P9/02;A61P11/02;A61P11/06;A61P13/02;A61P13/08;A61P13/10;A61P15/08;A61P17/02;A61P19/02;A61P25/00;A61P25/04;A61P25/06;A61P27/02;A61P29/00;A61P31/04;A61P31/10;A61P31/12;A61P37/08;A61P41/00;A61P43/00;C07C269/06;C07C271/22;C07C311/08;C07C311/21;C07D209/08;C07D209/12;C07D215/14;C07D217/24;C07D235/16;C07D235/18;C07D263/56;C07D307/12;C07D307/42;C07D307/54;C07D307/79;C07D307/80;C07D405/12;C07D405/14;C07D407/04;C07D409/04;(IPC1-7):C07C271/22;C07D309/04;C07D405/04;A61K31/325;A61K31/34;A61K31/38;A61K31/40;A61K31/42;A61K31/44;A61P7/04 |
主分类号 |
A61K31/198 |
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