METHOD OF PRODUCING 3-METHYL-2-THIOPHENECARBOXYLIC ACIDS

摘要

PROBLEM TO BE SOLVED: To provide a method for the easy production of a 3-methyl-2- thiophenecarboxylic acids at a low cost. SOLUTION: The 3-methyl-2-thiophenecarboxylic acids expressed by general formula (3) (R1 is H or a 1-8C alkyl) is produced by reacting a 3,4-dihalobutan-2- one expressed by general formula (1) (X1 and X2 are each independently a halogen atom) with a thioglycolic acids expressed by HSCH2COOR1 (R1 is H or a 1-8C alkyl) in the presence of a base.