OLIGONUCLEOTIDES WITH ACTIVITY AGAINST HUMAN IMMUNODEFICIENCY VIRUS

摘要

The present invention features compounds and methods for inhibiting propagat ion of human immunodeficiency virus (HIV). Preferred HIV target sites are identified and oligonucleotides designed to hybridize t o a target site are described. The preferred use of the oligonucleotides is as an anti-HIV agent to inhibit HIV propagation in a pat ient infected with HIV. Other uses of the present invent ion include detecting the presence of HIV by using the oligonucleotides as detec tion probes or amplification primers, and measuring the ability of an oligonucleotide to inhibit HIV propagation to evaluate its suitability as an anti-HIV agent for a phenotype of HIV or diagnose the presence of HIV in a patient.