发明名称 |
IDENTIFICATION OF HUMAN CYTOMEGALOVIRUS GENES INVOLVED IN DOWN-REGULATION OF MHC CLASS I HEAVY CHAIN EXPRESSION |
摘要 |
<p>The human cytomegalovirus (HCMV) genomic US region encodes a family of homologous genes essential for the inhibition of major histocompatiblity complex (MHC) class I mediated antigen presentation observed during viral infection. Here we show that US3 and US6 encode ER-resident glycoproteins that prevent intracellular transport of NMC class I molecules by different mechanisms. US3 retains stable MHC class I heterodimers in the ER which are loaded with peptides while retained in the ER. US6 prevents MHC class I assembly with beta 2 microglobulin which results in free heavy chains leaving the ER. These genes have the potential to prevent unwanted immunological reactivities triggered by MHC class I molecules.</p> |
申请公布号 |
EP0966301(A4) |
申请公布日期 |
2001.09.05 |
申请号 |
EP19970936334 |
申请日期 |
1997.07.31 |
申请人 |
ORTHO PHARMACEUTICAL CORPORATION |
发明人 |
FRUEH, KLAUS;YANG, YOUNG;AHN, KWANGSEOG |
分类号 |
A61K39/245;A61P37/02;C12N7/00;(IPC1-7):A61K39/245;C12N7/04;C12N15/09;C07H21/04 |
主分类号 |
A61K39/245 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|