| 摘要 |
<p>A process is claimed for producing sucralose, i.e. 4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose of formula (I), from a feed mixt. contg. (a) 6-O-acyl-sucralose (II), (b) salt including alkali metal or alkaline earth metal chloride, (c) water and (d) other chlorinated sucrose by-products, in a reaction medium contg. a tert. amide (III). The process involves: (i) deacylating (II) by raising the pH of the mixt. to 10-12, to give an aq. mixt. contg. (I), (b), (d) and (III); (ii) removing (III); and (iii) recovering (I) from the product. Alternatively the process involves: (i') removing (III) to give an aq. soln. of (II), (b) and (d) from which a major proportion of the (III) in the feed mixt. has been removed; (ii') deacylating as in (i), to give an aq. soln. contg. (I), (b) and (d); and (iii') recovering (I) from the product.</p> |
