发明名称 |
PARENTERAL PIMARICIN AS TREATMENT OF SYSTEMIC INFECTIONS |
摘要 |
An antifungal composition suitable for parenteral administration to a mammal includes an amount of pimaricin or an antifungal derivative thereof that is effective to inhibit the growth of a fungal infection in a mammal; a pharmaceutically acceptable dipolar aprotic solvent; and a pharmaceutically acceptable aqueous secondary solvent. The composition can be used in methods of preventing or treating a systemic fungal infection in a mammal. The composition can be prepared by dissolving pimaricin or an antifungal derivative thereof in the pharmaceutically acceptable dipolar aprotic solvent; adding to the solution a pharmaceutically acceptable aqueous secondary solvent; and in a preferred method, by subsequently lypohilizing the composition, whereby a dry, shelf-stable composition is produced. This dry composition can be reconstituted into an aqueous solution suitable for parenteral administration. |
申请公布号 |
EP1007013(A4) |
申请公布日期 |
2001.08.29 |
申请号 |
EP19980939905 |
申请日期 |
1998.08.07 |
申请人 |
BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
ANDERSSON, BORJE, S.;ANAISSIE, ELIAS, J. |
分类号 |
A61K9/08;A61K9/107;A61K9/19;A61K31/7048;A61K47/16;A61K47/18;A61K47/44;A61P31/10 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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