A family of ubiquitin-like proteins binds the atpase domain of hsp70-like stch

摘要

The present invention relates to the discovery of a domain on chaperone proteins that binds to ubiquitin-like proteins, including a novel protein Chap1/DSK2 (Ubiquilin-2). Novel biological tools, prophylactics, therapeutics, diagnostics, and methods of use of the foregoing are also disclosed.