发明名称 |
A 52 kDa PROTEIN FROM COAGULASE NEGATIVE STAPHYLOCOCCI AND FRAGMENTS THEREOF |
摘要 |
A protein isolated from <i>Staphylococcus epidermidis</i> having an approximate MW of 52 kD determined by SDS-PAGE and an N-terminal amino acid sequence (SEQ ID NO:1), and antigenic determinant-containing fragments of the protein, optionally coupled to an inert carrier or matrix, are disclosed. Disclosed are also a recombinant DNA molecule coding for the protein or the protein fragments; a vector comprising the DNA molecule or the corresponding RNA molecule; antibodies or antigen-binding peptides recognizing and specifically binding to the protein or protein fragment; use of the protein or protein fragment, or the vector, for the production of vaccines against Staphylococcal infections; use of the antibodies or antigen-binding peptides for the production of a medicament for passive immunization; a vaccine against Staphylococcal infections comprising the protein or protein fragment, or the vector; a medicament for passive immunization comprising the antibodies or antigen-binding peptides; and a method of prophylactic and/or therapeutic treatment of Staphylococcal infections.
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申请公布号 |
WO0160852(A1) |
申请公布日期 |
2001.08.23 |
申请号 |
WO2001SE00340 |
申请日期 |
2001.02.16 |
申请人 |
BIOSTAPRO AB;LJUNGH, AASA;DAI-QING, LI;LUNDBERG, FREDRIK |
发明人 |
LJUNGH, AASA;DAI-QING, LI;LUNDBERG, FREDRIK |
分类号 |
C12N15/09;A61K39/00;A61K39/085;A61K39/395;A61P31/04;C07K7/06;C07K14/31;C07K16/12;C07K17/08;C12N1/21;(IPC1-7):C07K14/31 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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