发明名称 |
Compositions and methods for inhibition of hiv-1 infection |
摘要 |
This invention provides a composition which comprises an admixture of two compounds, wherein one compound retards attachment of HIV-1 to a CD4+ cell by retarding binding of HIV-1 gp120 envelope glycoprotein to CD4 on the surface of the CD4+ cell and the other compound retards gp41 from adopting a conformation capable of mediating fusion of HIV-1 to a CD4+ cell by binding noncovalently to an epitope on a gp41 fusion intermediate, wherein the relative mass ratio of the compounds in the admixture ranges from about 100:1 to about 1:100, the composition being effective to inhibit HIV-1 infection of the CD4+ cell. This invention also provides a method of inhibiting HIV-1 infection of a CD4+ cell which comprises contacting the CD4+ cell with an amount of the above composition effective to inhibit HIV-1 infection of the CD4+ cell so as to thereby inhibit HIV-1 infection of the CD4+ cell. |
申请公布号 |
AU3118401(A) |
申请公布日期 |
2001.08.07 |
申请号 |
AU20010031184 |
申请日期 |
2001.01.26 |
申请人 |
PROGENICS PHARMACEUTICALS, INC. |
发明人 |
WILLIAM C. OLSON;PAUL J. MADDON |
分类号 |
A61K38/00;C07K14/16;C07K14/73 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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