ISOLATION AND STRUCTURE OF SPONGISTATIN 2, SPONGISTATIN 3, SPONGISTATIN 4 AND SPONGISTATIN 6

摘要

A black Spongia sp, in the Porifera class Demospongiae has been found to contain two new and exceptionally active cell (human cancers growth inhibitors,named spongistatin 2 and spongistatin 3. A bright colored Southwest Indian Ocean sponge Spirastrella spinispirulifera has also been found to contain related human cancer cell growth inhibitors named spongistatin 4 and spongistatin 6. A method of treating human cancer cells with spongistatin 1, spongistatin 2, spongistatin 3, spongistatin 4 and spongistatin 6 is also disclosed. The approximate mean GI50 of the disclosed compounds in the NCI cell line panel is about 10-10.mu.g/ml. 59