| 摘要 |
This invention provides smooth muscle cell proliferation inhibitors of formula I having the structurewhereinW is S, SO, SO2, NR;Y is O, S, NR, or CH2;R is hydrogen or alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, acyl of 2-7 carbon atoms, perfluoroacyl of 2-7 carbon atoms;R1 and R7 are each, independently, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, haloalkyl of 1-6 carbon atoms, nitroalkyl of 1-6 carbon atoms, cyanoalkyl of 1-6 carbon atoms, alkoxyalkyl of 2-12 carbon atoms, nitriloalkyl of 1-6 carbon atoms, phenyl mono-, di-, or tri-substituted with R8, phenylalkyl of 7-10 carbon atoms, wherein the phenyl ring is mono-, di-, or tri-substituted with R8, pyridyl substituted with R8, furyl substituted with R8, thienyl substituted with R8, and thiazolyl substituted with R8;R2 is hydrogen,R3, R4, R5, and R6 are each, independently, hydrogen, acyl of 2-7 carbon atoms, perfluoroacyl of 2-7 carbon atoms, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, benzyl, wherein the phenyl moiety is mono-, di-, or tri-substituted with R8, benzoyl, wherein the phenyl moiety is mono-, di-, or tri-substituted with R8;R8 is hydrogen, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, perfluoroalkoxy of 1-6 carbon atoms, phenyl, -CN, -NO2, halogen, or -CF3;R9 is hydrogen, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, perfluoroalkoxy of 1-6 carbon atoms, phenyl, -CN, -NO2, halogen, -NHCO2R13, -NHSO2R13, -NR14R15,R10, R11, and R12, are each, independently, hydrogen, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, perfluoroalkoxy of 1-6 carbon atoms, phenyl, -CN, -NO2, halogen, acyl of 2-7 carbon atoms, perfluoroacyl of 2-7 carbon atoms, or benzoyl, wherein the phenyl moiety of the benzoyl group is optionally mono-, di-, or tri-substituted with alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, -CN, -NO2, halogen, or -CF3;R13 is alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, phenyl or phenyl substituted with halogen;R14 and R15 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, acyl of 2-7 carbon atoms, perfluoroacyl of 2-7 carbon atoms;n=0-3; or a pharmaceutically acceptable salt thereof.
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