发明名称 APOLIPOPROTEIN-B SYNTHESIS INHIBITORS
摘要 <p>PCT No. PCT/EP95/04111 Sec. 371 Date Apr. 9, 1997 Sec. 102(e) Date Apr. 9, 1997 PCT Filed Oct. 19, 1995 PCT Pub. No. WO96/13499 PCT Pub. Date May 9, 1996The present invention provides novel compounds of formula the N-oxides, the stereochemically isomeric forms thereof, and the pharmaceutically acceptable acid addition salts thereof, wherein A and B taken together form a bivalent radical of formula: -N=CH- (a), -CH=N- (b), -CH2-CH2- (c), -CH=CH- (d), -C(=O)-CH2- (e), -CH2-C(=O)- (f); R1 is hydrogen, C1-6alkyl, or halo; R2 is hydrogen or halo; R3 is hydrogen; C1-8alkyl; C3-6cycloalkyl or C1-8alkyl substituted with hydroxy, oxo, C3-6cycloalkyl or aryl. Het is five- or six-membered optionally substituted heterocyclic ring. The use as a medicine, especially as a lipid lowering agent is disclosed as well as pharmaceutical compositions and processes for preparing compounds and compositions.</p>
申请公布号 GR3035519(T3) 申请公布日期 2001.06.29
申请号 GR20010400359T 申请日期 2001.03.05
申请人 JANSSEN PHARMACEUTICA N.V. 发明人 HEERES, JAN;BACKX, LEO, JACOBUS, JOZEF;HENDRICKX, ROBERT, JOZEF, MARIA;VAN DER EYCKEN, LUC, ALFONS, LEO;DE CHAFFOY DE COURCELLES,DIDIER ROBERT GUY GABRIEL
分类号 C07D405/12;A61K31/41;A61K31/495;A61P3/06;A61P9/12;C07D405/14;C07D413/14;C07D417/14;(IPC1-7):C07D405/14 主分类号 C07D405/12
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