COMPOSITIONS, SYSTEMS, AND METHODS FOR CREATING IN SITU, CHEMICALLY CROSS-LINKED, MECHANICAL BARRIERS OR COVERING STRUCTURES

摘要

A biocompatible and biodegradable material is applied to a tissue region, e.g., to seal a vascular puncture site, or to arrest the flow of blood or fluid from body tissue, or to arrest diffuse bleeding. The material preferably includes a protein comprising recombinant or natural serum albumin, which is mixed with a polymer that comprises poly(ethylene) glycol (PEG), and, most preferably, a multi-armed PEG polymer.