发明名称 |
PROCESS FOR THE SELECTIVE PREPARATION OF Z-ISOMERS OF 3-(2-SUBSTITUTED VINYL)CEPHALOSPORINS |
摘要 |
<p>Z-Isomers of compounds of general formula (IV): Äwherein R<1> is 2-(2-N-protected aminothiazol-4-yl)-2-alkoxyiminoacetyl or the like, R<1> is hydrogen or the like; R<3> is hydrogen, a carboxyl-protecting group or the like; and R<1> is alkyl or the likeÜ can be prepared at high selectivities and in high yields by reacting a compound of general formula (I): Äwherein R<1>, R<2> and R<3> are each as defined above; and R<4> is aryl or the likeÜ with a 4-substituted or -unsubstituted thiazole-5-carbaldehyde in a mixed solvent comprising a chlorinated hydrocarbon and a lower alkanol at a temperature of as low as +5 DEG C or below. <CHEM></p> |
申请公布号 |
EP1016665(A4) |
申请公布日期 |
2001.06.13 |
申请号 |
EP19980929666 |
申请日期 |
1998.06.24 |
申请人 |
MEIJI SEIKA KAISHA, LTD. |
发明人 |
OKADA, YUMIKO;SUKEGAWA, MASAMICHI;WATANABE, TATSUO;IWASAWA, HIROYUKI;MURAI, YASUSHI;IINUMA, KATSUHARU |
分类号 |
A61K31/545;C07D501/00;C07D501/04;C07D501/12;C07D501/24;(IPC1-7):C07D501/04;C07M9/00 |
主分类号 |
A61K31/545 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|