| 摘要 |
In the present invention there is disclosed the use of aromatic carboxylic acid derivatives of the general formula I, in which Re1 represents the radical of the general formula a or b; Re2 represents alkanoyl having 2 to 8 carbon atoms, alkyl containing 2 to 8 carbon atoms, alkenyl with 2 to 8 carbon atoms, alkynyl containing 2 to 8 carbon atoms or -OCHi2Re3; Re3 represents hydrogen, alkyl with 1 to 6 carbon atoms, alkenyl containing 2 to 6 carbon atoms or alkynyl having 2 to 6 carbon atoms; Re4 to Re9 represents each independently on each other hydrogen H or alkyl with 1 to 5 carbon atoms; or Re8 and Re9 together represent (CReaReb)in, in which Rea and Reb represents each hydrogen H or alkyl with 1 to 5 carbon atoms, n is 1, 2 or 3 and Re4 to Re7 are as specified above; or Re8 and Re9 together are (CReaReb)in, and Re4 and Re6 are together an optionally hydroxy substituted methylene or ethylene and Rea and Reb, Re5, Re7 and n are as specified above; and Re10 represents carboxy, alkoxycarbonyl having 1 to 6 carbon atoms in the alkoxyl moiety or mono- or dialkylcarbamoyl containing 1 to 6 carbon atoms in each alkyl moiety; whereby dashed line in the radical formula represents a facultative bond. The present invention relates also to use of pharmaceutically acceptable salts of carboxylic acids of the general formula I for preparing pharmaceutical preparations intended for treating and prophylaxis of skin lesion caused by light or age, as well as for enhancement of wound healing. The above-indicated derivatives, in which Re2 represents alkanoyl containing 2 to 8 carbon atoms or in which Re2 represents -OCHi2Re3 and Re3 represents alkenyl having 2 to 8 carbon atoms or alkynyl with 2 to 8 carbon atoms form part of the present invention, too. |
