| 摘要 |
The invention relates to an excipient system that can be obtained by (1) optionally mixing a component a2) with a component a1) in a molar ratio [a2):a1)] of 1:1 to 1000:1, preferably between 10:1 and 100:1, (2) mixing th e complex resulting from step (1) or the complex a1) alone with a component b1 ), preferably in a molar ratio b1):a1) + optionally a2) of 1:1 to 1:1000, said mixing ratio being adjusted in such a manner that the net charge of the resulting total complex is preferably neutral or anionic. Component a1) comprises an active substance a1), a binding structure a1) for the binding structures b1) or a2), wherein the active substance a1) may contain the binding structure a1). Component a2) comprises a binding structure a2) for t he binding structure a1) and a carrier a2) which may contain the binding structure a2). Component b1) may comprise a binding structure b1) for the binding structure a1), for the active substance a1), for the binding structu re a2) or for the carrier a2), a coating substance that may contain the binding structure b1), an enzymatically removable connector, and an anionic side- group. The invention further relates to the production and to the use of the inventive excipient system.
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