发明名称 |
BONZO CHEMOKINE RECEPTOR ANTIBODIES AND LIGANDS |
摘要 |
The invention relates to an antibody or antigen-binding fragment thereof which binds to the CXC chemokine receptor Bonzo (also referred to as STRL33, TYMSTR, HBMBU14 and CXCR6) and blocks the binding of a ligand (e.g., SExCkine (also referred to as chemokine alpha-5 and CXCL16) to the receptor. The invention also relates to a method of identifying agents (molecules, compounds) which can bind to Bonzo and inhibit the binding of a ligand (e.g. SExCkine) and/or modulate a function of Bonzo. The invention relates to an antibody or antigen-binding fragment thereof which binds to the CXC chemokine SExCkine (also referred to as chemokine alpha-5) and inhibit binding of SExCkine to receptor (e.g., Bonzo). The invention also relates to targeting molecules which contain a first binding moiety which binds to mammalian Bonzo and a second binding moiety which binds to a molecule expressed on the surface of a target cell. The invention also relates to a method of promoting and/or effectuating the interaction of a Bonzo<+> cell and a target cell. The invention further relates to a method of modulating a function of Bonzo, and to the use of the antibodies, antigen-binding fragments, targeting molecules and agents identified by the method of the invention in research, therapeutic, prophylactic and diagnostic methods.
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申请公布号 |
WO0137872(A1) |
申请公布日期 |
2001.05.31 |
申请号 |
WO2000US32206 |
申请日期 |
2000.11.22 |
申请人 |
MILLENNIUM PHARMACEUTICALS, INC. |
发明人 |
BRISKIN, MICHAEL, J.;MURPHY, KRISTINE, E.;WILBANKS, ALYSON, M.;WU, LIJUN |
分类号 |
A61K38/00;A61K39/00;C07K14/715;C07K16/24;C07K16/28;(IPC1-7):A61K39/395;A61K45/00;G01N33/53;C07K14/52;C07K16/46 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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