发明名称 |
HUMAN ENZYMES OF THE METALLOPROTEASE FAMILY |
摘要 |
<p>This invention relates to newly identified, polypeptides and polynucleotides encoding such polypeptides, which hereinafter are referred to as IGS5, to their use in therapy and in identifying compounds which may be stimulators and/or inhibitors which are potentially useful in therapy, and to production of such polypeptides and polynucleotides. The polypeptides and polynucleotides are related to the metalloprotease family and preferably of human type. The invention also relates to inhibiting or stimulating/activating the action of such polypeptides and polynucleotides, to a vector containing said polynucleotides and to a host cell containing such vector. The invention further relates to a method for screening compounds capable to act as a stimulator or inhibitor of said IGS5 enzyme. The Polypeptides of the present invention are of interest in the context of several dysfunctions, disorders or diseases. The Polypeptides of the present invention are in particular of interest in the context of cardiovascular diseases.</p> |
申请公布号 |
WO0136610(A1) |
申请公布日期 |
2001.05.25 |
申请号 |
WO2000EP11532 |
申请日期 |
2000.11.17 |
申请人 |
SOLVAY PHARMACEUTICALS B.V.;DELEERSNIJDER, WILLY;WIEGERS, RICO;WESKE, MICHAEL |
发明人 |
DELEERSNIJDER, WILLY;WIEGERS, RICO;WESKE, MICHAEL |
分类号 |
G01N33/50;A61K38/46;A61K38/48;A61K45/00;A61K48/00;A61P1/04;A61P1/08;A61P1/12;A61P3/04;A61P3/10;A61P7/02;A61P7/10;A61P9/04;A61P9/06;A61P9/10;A61P9/12;A61P11/06;A61P13/08;A61P13/12;A61P19/02;A61P19/10;A61P25/00;A61P25/04;A61P25/06;A61P25/08;A61P25/14;A61P25/16;A61P25/18;A61P25/20;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P25/36;A61P29/00;A61P31/04;A61P31/10;A61P31/12;A61P31/18;A61P33/02;A61P35/00;A61P37/00;A61P37/08;C07K16/40;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/64;C12N9/99;C12N15/09;C12N15/57;C12Q1/37;C12Q1/68;G01N33/15;(IPC1-7):C12N9/64 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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