发明名称 |
TREATMENT OF B CELL MALIGNANCIES USING ANTI-CD40L ANTIBODIESIN COMBINATION WITH ANTI-CD20 ANTIBODIES AND/OR CHEMOTHERAPEUTICS AND RADIOTHERAPY |
摘要 |
The invention discloses compositions, combination therapies and methods of treating B-cell lymphomas and leukemias, as well as other CD40+ malignancies . The primary active agent of the composition is an anti-CD40L antibody or oth er CD40L antagonist that inhibits CD40-CD40L interaction. Compositions may additionally contain or utilize any one or more of the following in combination for the treatment of said disease: anti-CD20 antibodies, chemotherapeutic agents, chemotherapy cocktails, and radiotherapy.
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申请公布号 |
CA2390412(A1) |
申请公布日期 |
2001.05.17 |
申请号 |
CA20002390412 |
申请日期 |
2000.11.06 |
申请人 |
IDEC PHARMACEUTICALS CORPORATION |
发明人 |
HANNA, NABIL;HARIHARAN, KANDASAMY |
分类号 |
A61K41/00;A61K39/395;A61K45/00;A61K51/00;A61K51/10;A61P35/00;A61P35/02;C07K16/28;(IPC1-7):A61K39/395 |
主分类号 |
A61K41/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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