发明名称 |
Antibodies to S. mutans and uses thereof |
摘要 |
The invention describes three monoclonal IgG antibodies, referred to as SWLA1, SWLA2, and SWLA3, which appear to recognize a species-specific lipooligosaccharide or lipopolysaccharide on the cell surface of S. mutans. The invention also describes a rapid method of detection of S. mutans without the need for prior growth of the bacteria in culture. The invention further describes a methods of utilizing these antibodies for rapidly quantitatively detecting S. mutans. These methods are sensitive enough to detect the presence of a single S. mutans bacterial cell. These methods can be widely used in the clinical diagnosis and treatment of dental caries in humans.
|
申请公布号 |
US6231857(B1) |
申请公布日期 |
2001.05.15 |
申请号 |
US19990378247 |
申请日期 |
1999.08.20 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
SHI WENYUAN;HUME WYATT R. |
分类号 |
C07K16/12;(IPC1-7):A61K39/40 |
主分类号 |
C07K16/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|