Methods for the preparation of (lipo)peptide synthetases and (lipo)peptides produced therewith

摘要

The present invention relates to methods for the preparation of novel lipopeptide synthetases, to the lipopeptide synthetases thus obtained and the lipopeptides that are produced by these synthetases. The method involves modifying at least the lipid moiety and optionally also the peptide moiety of one or more known (lipo)peptide synthetase. The invention further provides DNA molecules encoding such lipopeptide synthetase, libraries containing DNA fragments encoding modules of such lipopeptide synthetases and the use of both.