METHOD OF FORMING MICROPORES IN SKIN

摘要

A method of forming pores (600) in the stratum corneum (210) includes applyi ng an aqueous material (123) to a surface area of the stratum corneum followed by the application of sonic and/or ultrasonic radiation (112) to said aqueous material wherein said sonic and/or ultrasonic radiation has a frequency in t he range of 10KHz and 5 MHz and is applied at an intensity, for a period of tim e and at a distance from said surface area of the stratum corneum effective to generate cavitation bubbles (500) on said surface area of the stratum corneu m, wherein said cavitation bubbles collapse and transfer their energy into the stratum corneum causing the formation of pores. Large size molecules ( > 500Da) dissolved in the aqueous material can transfer through these pores an d across the stratum corneum and reach the blood vessels at flow rates suitabl e for therapeutic applications.