| 摘要 |
The present invention provides a novel method for monitoring the degradation of biodegradable polymers including, but not limited to, polyesters and polyanhydrides, at the molecular level, to provide detailed information on degradation rates, exploring degradation kinetics and mechanism, by using Time-of-Flight Secondary Ion Mass Spectrometry (ToF SIMS) measurements. The method comprises (1) preparing polymer specimen to predetermined dimensions; (2) initiating the desired degradation reaction in vitro; (3) monitoring the degradation process with a ToF SIMS instrument by measuring the degradation products generated; (4) conducting data reduction which can provide detailed information on degradation rates, kinetics and mechanisms of the degradation. |
