MODIFIED VIRAL SURFACE PROTEINS WHICH BIND TO CELLS OF TUMORVASCULATURE

摘要

A vector particle having a surface protein which is modified to include a tumor vasculature targeting motif, or TVTM, peptide. Such peptides enable vector particles to be targeted to endothelial cells, and in particular to endothelial cells of the blood vessels of tumors, whereby agents which inhibit, prevent, or destroy th growth of such cells are delivered to the cells, thereby terminating the blood supply to a tumor.