发明名称 |
Method of detecting autoantibody present in the serum of rheumatic |
摘要 |
A reagent for immunologically detecting rheumatism containing as an antigen at least one mammalian protein selected from among ezrin, radixin and moesin and/or a peptide composed of at least nine consecutive amino acid residues found in the amino acid sequences of ezrin, radixin and moesin; and a method of detecting autoantibodies present in the serum of a rheumatic. An immunological reaction using this reagent enables precritical or early diagnosis of rheumatism. An immunological detection using the above autoantigenic proteins is convenient and reliable as an early serodiagnostic method based on rheumatism-specific antigens.
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申请公布号 |
US6225442(B1) |
申请公布日期 |
2001.05.01 |
申请号 |
US19990235283 |
申请日期 |
1999.01.22 |
申请人 |
DADE BEHRING MARBURG GMBH;HOECHST MARION ROUSSEL LTD. |
发明人 |
WAGATSUMA MASAKO;KIMRUA MICHIO;WATANABE HIROSHI;TAKEUCHI FUJIO |
分类号 |
G01N33/564;G01N33/68;(IPC1-7):A61K38/04 |
主分类号 |
G01N33/564 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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