发明名称 |
DERIVATIVES OF PIPERAZINE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT OF PATIENTS WITH 8-OH-DPAT SYNDROME |
摘要 |
organic chemistry, pharmacy. SUBSTANCE: invention describes novel derivatives of piperazine of the general formula (A) where Ra and Rb each means hydrogen atom or methyl group; Rc means hydrogen atom or its pharmaceutically acceptable acid additive salt. New compounds can be used as agent binding 5-HT1A receptors, in part, as antagonists of 5-HT1A receptors and they are useful for treatment of patients with central nervous system disorders. Invention relates to also methods of their synthesis, their using and pharmaceutical preparations containing thereof. EFFECT: new piperazine derivatives indicated above, improved method of synthesis, valuable medicinal properties. 7 cl, 2 tbl |
申请公布号 |
RU2165933(C2) |
申请公布日期 |
2001.04.27 |
申请号 |
RU19970100151 |
申请日期 |
1995.06.01 |
申请人 |
DZHON VAJS EHND BRAZER LIMITED |
发明人 |
KRISTOFER JAN BRAJTUELL;MAJKL GERARD KELLI |
分类号 |
A61K31/395;A61K31/495;A61P25/18;A61P25/20;A61P25/24;A61P25/26;A61P43/00;C07D401/12 |
主分类号 |
A61K31/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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