发明名称 |
PHARMACEUTICAL COMPOSITION FOR TREATMENT OF MUCOSAL EPITHELIAL ULCERATION AND/OR EROSION |
摘要 |
A bioadhesive pharmaceutical composition for treatment of mucosal epithelial ulceration and/or erosions, said composition comprising: (i) a bioadhesive substance; (ii) a biologically active substance having MMP inhibitory activity; and (iii) an optional physiologically acceptable vehicle; said bioadhesive substance and optional physiologically acceptable vehicle being selected to release the biologically active substance in a therapeutic amoun t into the epithelia of the mucosa without affecting the normal flora thereof; use of the composition for the manufacture of a medicament for treating mucosal ulceration and/or erosion; a method of treating mucosal epithelial ulceration and/or erosion in a mammal; and a method of delivering a biologically active substance to the mucosa of a mammal for treatment of mucosal epithelial ulceration and/or erosion.
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申请公布号 |
CA2386422(A1) |
申请公布日期 |
2001.04.26 |
申请号 |
CA20002386422 |
申请日期 |
2000.10.22 |
申请人 |
LIF-HLAUP EHF. BIO-GELS PHARMACEUTICALS INC. |
发明人 |
SKULASON, SKULI;HOLBROOK, W. PETER;GIZURARSON, SVEINBJORN;KRISTMUNDSDOTTIR, THORDIS |
分类号 |
A61K9/02;A61K9/00;A61K9/06;A61K9/08;A61K9/10;A61K9/12;A61K9/127;A61K9/48;A61K9/70;A61K31/00;A61K31/085;A61K31/135;A61K31/14;A61K31/167;A61K31/235;A61K31/245;A61K31/327;A61K31/352;A61K31/4418;A61K31/4704;A61K31/5375;A61K31/60;A61K31/65;A61K33/22;A61K33/30;A61K35/60;A61K36/06;A61K36/47;A61K45/00;A61K47/32;A61K47/34;A61K47/36;A61K47/38;A61K47/42;A61K47/46;A61P1/00;A61P1/02;A61P1/04;A61P11/00;A61P15/00;A61P15/02;A61P27/16;A61P29/00;A61P43/00;(IPC1-7):A61K9/00;A61K47/00;A61K47/30 |
主分类号 |
A61K9/02 |
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