发明名称 |
PROCESS FOR PRODUCING ASPARTAME DERIVATIVE, CRYSTALS THEREOF, NOVEL PRODUCTION INTERMEDIATES THEREFOR AND PROCESS FOR PRODUCING THE INTERMEDIATE |
摘要 |
3-(3-Hydroxy-4-methoxyphenyl)-3-methylbutyl aldehyde is produced by a reaction whereby the carboxyl group in 3-(3-hydroxy-4-methoxyphenyl)-3-methylbutyric acid, which can be obtained by reacting a 2-halogenoanisole with 3-methylcrotonic acid and converting the halogen atom in the thus produced 3-(3-halogeno-4-methoxyphenyl)-3-methylbutyric acid into a hydroxyl group, is converted into a formyl group. By a reductive alkylation reaction with aspartame, this aldehyde derivative can be easily and efficiently converted on an industrial scale into N-[N-[3-(3-hydroxy-4-methoxyphenyl)-3-methylbutyl]-L- alpha -aspartyl]-L-phenylalanine 1-methyl ester which is useful as a sweetener having a high degree of sweetness. Thus, the aldehyde derivative is highly excellent as an intermediate for the production of the sweetener. |
申请公布号 |
WO0127142(A1) |
申请公布日期 |
2001.04.19 |
申请号 |
WO2000JP06933 |
申请日期 |
2000.10.04 |
申请人 |
AJINOMOTO CO., INC.;KAWAHARA, SHIGERU;NAGASHIMA, KAZUTAKA;MORI, KENICHI;TAKEMOTO, TADASHI;ONO, ERIKO |
发明人 |
KAWAHARA, SHIGERU;NAGASHIMA, KAZUTAKA;MORI, KENICHI;TAKEMOTO, TADASHI;ONO, ERIKO |
分类号 |
A23L27/30;C07C45/41;C07C45/79;C07C47/277;C07C51/367;C07C59/64;C07K5/072;C07K5/075 |
主分类号 |
A23L27/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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