5-aralkyl or (aryl, heteroaryl or heteroarylalkyl) substituted pyrrolo[3,4-d]pyrimidinone derivatives and medicaments

摘要

There is provided certain 5-substituted pyrrolo[3,4-d]pyrimidine-2,4-diones according to the general formula (I), processes for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and the use of the compounds of formula (I) for the manufacture of medicaments for use in therapy. wherein W represents --CH2 - or a bond; Q represents Ar1 or Ar2 ; in the case where W represents --CH2 -, Q represents an aryl group Ar1 wherein Ar1 represents naphthyl, phenyl, quinolyl, isoquinolyl, indolyl, benzofuranyl or benzothienyl; in the case where W represents a bond, Q represents an aryl group Ar2 wherein Ar2 represents acenaphthenyl, fluorenyl or indanyl; wherein the ring systems which Ar1 and Ar2 represent may all be optionally substituted by one or more substituents selected from C1-4 alkyl, C1-4 alkoxy, halogen, or trifluoromethyl; R10 represents X-(A)p -Y; X represents S(O)n, CºC, (CH2)2, CH=CH or CH2CH=CH; n represents 0, 1 or 2; A represents C1-6 alkylene; p is 0 or 1; Y represents CN, OR11, CO2 R12, CONR13 R14, NR15 R16, NHSO2 R17, NHCOR18 or an optionally substituted aryl or heteroaryl group, provided that when X represents S(O)n and Y is other than an optionally substituted aryl or heteroaryl group, then p is 1 and also provided that when X represents S(O)n, p is 1 and Y represents OH, then n is not 0; R13 and R14 independently represent H, C1-5 alkyl or phenyl, which latter group may be substituted by one or more substituents selected from C1-4 alkyl, C1-4 alkoxy, halogen, or CO2 R21 ; and R1, R2, R11, R12, R15, R16, R17, R18, and R21 independently represent H or C1-5 alkyll; or a pharmaceutically acceptable salt thereof.