DOSAGE FORM FOR AEROSOL ADMINISTRATION OF WATER-SENSITIVE MEDICAMENTS

摘要

A method for preparing aerosols of water-sensitive medicaments and a pharmaceutical kit for aerosol administration are disclosed. The kit includes (a) a solid state open matrix network of a medicament in a first container; and (b) an aqueous vehicle in a second container. The first and second containers may be separate or they may be chambers within a single housing. The solid state network may be a unit dose of medicament, and the quantity of aqueous vehicle will then be that quantity needed to deliver one unit dose by aerosol; alternatively, the solid state network may contain a plurality of unit doses of medicament, in which case the quantity of aqueous vehicle will be that quantity needed to deliver the number of unit doses in the network. The kit may also include a metered dose nebulizer. A preferred medicament for use in the method is formoterol.