RECOMBINANT ANTIBODIES SPECIFIC FOR TNF-.ALPHA.

摘要

Recombinant, in particular humanised, e.g. humanised chimeric and CDR-grafte d humanised, antibody molecules having specificity fox human TNF.alpha., are provided for use in diagnosis and therapy. In particular the antibody molecules have antigen binding sites derived from murine monoclonal antibodies CB0006, CB0010, hTNF 3 or 101.4. Preferred CDR-grafted humanised anti-hTNF.alpha. antibodies comprise variable region domains comprising huma n acceptor framework and donor antigen binding regions and wherein the frameworks comprise donor residues at specific positions. The antibody molecules may be used for therapeutic treatment of human patients suffering from or at risk of disorders associate d with undesirably high Levels of TNF, in particular for treatment of immunoregulatory and inflammatory disorders or of septic, endotoxic or cardiovascular shock.