发明名称 |
Vector for tissue-specific replication and gene expression |
摘要 |
The invention generally relates to cell-specific expression vectors. It particularly relates to targeted gene therapy using recombinant expression vectors and particularly adenovirus vectors. The invention specifically relates to replication-conditional expression vectors and methods for using them. Such vectors are able to selectively replicate in a target cell or tissue to provide a therapeutic benefit in a tissue from the presence of the vector per se or from one or more heterologous gene products expressed from the vector and distributed throughout the tissue. In such vectors, a gene essential for replication is placed under the control of a heterologous tissue-specific transcriptional regulatory sequence. Thus, replication is conditioned on the presence of a factor(s) that induces transcription or the absence of a factor(s) that inhibits transcription of the gene by means of the transcriptional regulatory sequence with this vector; therefore, a target tissue can be selectively treated. |
申请公布号 |
AU1755299(A) |
申请公布日期 |
1999.06.07 |
申请号 |
AU19990017552 |
申请日期 |
1998.11.17 |
申请人 |
NOVARTIS AG |
发明人 |
PAUL L HALLENBECK;CARL M. HAY;DAVID A. STEWART |
分类号 |
C12N15/09;A61K31/711;A61K35/76;A61K38/00;A61K38/44;A61K39/23;A61K39/235;A61K39/245;A61K39/29;A61K48/00;A61P35/00;C12N5/10;C12N7/00;C12N7/01;C12N15/861 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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