发明名称 |
PYRIDO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS |
摘要 |
A class of pyrido[2,3-<i>d</i>]pyridazine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 8-position, a substituted alkoxy moiety at the 2-position, and a range of substituents at the 3-position, are selective ligands for GABAA receptors, in particular having high affinity for the alpha 2 and/or alpha 3 and/or alpha 5 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.
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申请公布号 |
WO0118001(A1) |
申请公布日期 |
2001.03.15 |
申请号 |
WO2000GB03353 |
申请日期 |
2000.08.30 |
申请人 |
MERCK SHARP & DOHME LIMITED;CARLING, WILLIAM, ROBERT;CASTRO PINEIRO, JOSE, LUIS;MITCHINSON, ANDREW;STREET, LESLIE, JOSEPH |
发明人 |
CARLING, WILLIAM, ROBERT;CASTRO PINEIRO, JOSE, LUIS;MITCHINSON, ANDREW;STREET, LESLIE, JOSEPH |
分类号 |
A61K31/5025;A61P9/00;A61P9/10;A61P25/00;A61P25/08;A61P25/16;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P31/18;A61P43/00;C07D471/04;(IPC1-7):C07D471/04;A61K31/502 |
主分类号 |
A61K31/5025 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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