PROCESS FOR PRODUCING BETA-LACTAM DERIVATIVES

摘要

A process for preparing a beta -lactam derivative represented by the formula (2) A-COOH wherein A is a residue of the beta -lactam derivative, the process being characterized in that a beta -lactam derivative having a protected carboxyl group which derivative is represented by the formula (1) A-COO-X wherein A is as defined above and X is a benzyl group which may have an electron-donating group as a substituent on a phenyl ring or a diphenylmethyl group which may have an electron-donating group as a substituent on a phenyl ring, is treated with aluminum halide in an aliphatic ether solvent to give the derivative of the formula (2); and that the removed group X can be recovered as X-OH for reuse.