Sulfonamide derivative, process of its preparation and pharmaceutical preparation in which it is comprised

摘要

In the present invention there is disclosed a sulfonamide derivative of the general formula I, in which -A=B-C=D- -CH=CH-CH=CH-, wherein 1 CH is optionally substituted with nitrogen, Ar represents phenyl or naphthyl being optionally substituted or 1, 2 or 3 hydrogen atoms, halogen atoms Q or Ph, Re1, Re2 and Re3 represent independently on each other hydrogen atoms, halogen atoms or Q, Re4 and Re5 represents independently on each other a hydrogen atom or Q, Q represents alkyl containing 1 to 6 carbon atoms, Ph represents phenyl, X represents oxygen or sulfur, Hal represents fluorine, chlorine, bromine or iodine, a is 1, 2 or 3 as well as salts thereof exhibit endothelin receptor antagonistic properties and therefore they are suitable for preparing pharmaceutical preparations.