Methods for the induction of broadly anti-HIV-1 neutralizing antibody responses employing liposome-MPER peptide compositions

摘要

The present invention relates in general, to a formulation suitable for use in inducing anti-HIV-1 antibodies, and, in particular, to a formulation comprising Toll Like Receptor (TLR) agonists with HIV-1 gp41 membrane proximal external region (MPER) peptide-liposome conjugates for induction of broadly reactive anti-HIV-1 antibodies. The invention also relates to methods of inducing neutralizing anti-HIV-1 antibodies using such formulations.

主权项

1. A method of inducing the production in a subject of anti-HIV-1 antibodies comprising administering to said subject a composition comprising a liposome-peptide conjugate in an amount sufficient to effect said induction, wherein said peptide comprises SEQ ID NO:17 (NEQELLELDKWASSWNWFNITNWLWYIK) presented on the surface of said liposome.