发明名称 |
Human therapeutic uses of BPI protein products |
摘要 |
Disclosed are methods for treatment of humans exposed to bacterial endotoxin in circulation by administration of bactericidal/permeability-increasing (BPI) protein products. Serologically and hematologically verifiable alleviation of endotoxin mediated increases in circulating cytokines, fibrinolysis and coagulation factors and changes in lymphocyte counts are observed upon such treatment. Also observed is alleviation of endotoxin mediated decreases in systemic vascular resistance index (SVRI) and concomitant increases in cardiac index (CI).
|
申请公布号 |
US6191112(B1) |
申请公布日期 |
2001.02.20 |
申请号 |
US19990388758 |
申请日期 |
1999.09.02 |
申请人 |
XOMA CORPORATION |
发明人 |
FRIEDMANN NADAV;SCANNON PATRICK J.;VAN DEVENTER SANDER J. H.;VON DER MOHLEN MARIJKE A. M.;WEDEL NANCY |
分类号 |
A61K38/00;A61K38/17;A61K45/00;A61P31/00;A61P31/04;A61P37/00;C07K14/47;(IPC1-7):A61K38/00;A61K45/05 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|