| 摘要 |
PROBLEM TO BE SOLVED: To obtain an immunomodulator from which protection against the internal infection of Escherichia coil, Bacillus dysentericus and Salmonella and the prevention and reduction of rheumatic arthritis and immune-related diseases such as Crohn disease and ulcerative colitis can be expected and which is useful as a safe raw material for foods, by including the killed cells of a specific lactobacillus as an active ingredient. SOLUTION: This immunomodulator contains the killed cells of Enterococcus faecalis AD101 strain (international accession number BP-297) as an active ingredient. The killed cells are preferably taken at a daily dose of 50 mg to 1 g as dry weight for man. The immunomodulator is preferably produced by a method comprising washing the Enterococcus faecalis AD101 strain with water such as distilled water, suspending the washed cells in water, subjecting the cells to a hot water-heating sterilization treatment at 60 to 125 deg.C for 1 to 60 min, and, if necessary, then drying the sterilized cells into powdery fine particles by a spray-drying method, a freeze-drying method or the like. |
