发明名称 |
THE INTERACTION OF SMAD6 WITH HOX PROTEINS AND USES THEREOF |
摘要 |
The present invention describes a novel interaction between Smad6 and the Hox genes in nuclear transcriptional regulation following BMP signal transduction. The present invention further provides methods of using this novel Smad6/Hox protein interaction to regulate gene expression, regulate bone formation and control osteoporosis. Further provided are methods of screening for compounds that interfere with the novel Smad6/Hox protein interaction, thereby resulting in expression of a Hox protein-repressed gene and/or stimulating bone formation.
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申请公布号 |
WO0111013(A2) |
申请公布日期 |
2001.02.15 |
申请号 |
WO2000US40563 |
申请日期 |
2000.08.03 |
申请人 |
UAB RESEARCH FOUNDATION |
发明人 |
CAO, XU;SHI, XINGMING;BAI, SHUTING |
分类号 |
A61K38/00;C07K14/47;G01N33/68;(IPC1-7):C12N/ |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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