| 摘要 |
PROBLEM TO BE SOLVED: To provide a preparation method, for a virus antigen, in which the virus antigen with increased antigen activity can be obtained. SOLUTION: This preparation method is composed of a process in which a virus antigen is changed into low molecules or modification-treated by at least one kind selected from a group composed of a surface-active agent, a reducing agent and a protein modifier. In addition, the preparation method is composed of a process wherein the virus antigen which is changed into low molecules or modification-treated is diluted or dialyzed with an oxidizing-agent solution. The virus antigen is expressed by a gene recombination method in which bacteria or yeast are used as the host.
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