发明名称 |
Cloned peripheral nerve, tetrodotoxin-resistant sodium channel alpha-subunit |
摘要 |
The present invention relates to a voltage-gated sodium channel present in peripheral nerve tissue that is tetrodotoxin-resistant. One aspect of the present invention is purified and isolated DNA encoding this sodium channel. Another aspect of the present invention is the recombinant protein expressed by this DNA, expression vectors comprising the DNA sequence, and host cells transformed with these expression vectors. Another aspect of this invention is the use of this voltage-gated, tetrodotoxin-resistant sodium channel as a therapeutic target for compounds to treat disorders of the peripheral nervous system.
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申请公布号 |
US6184349(B1) |
申请公布日期 |
2001.02.06 |
申请号 |
US19970843417 |
申请日期 |
1997.04.15 |
申请人 |
SYNTEX (USA) INC. |
发明人 |
HERMAN RONALD;DELGADO STEPHEN GREGORY;FISH LINDA MARIE;SANGAMESWARAN LAKSHMI;RABERT DOUGLAS KENNETH |
分类号 |
C07K14/705;C12N15/12;(IPC1-7):C07K14/435;C07K14/00 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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