| 摘要 |
<p>The present invention provides a method for determining the presence of a multidrug resistance (MDR) pump inhibitor in a natural antibiotic producing source, including plants and microorganisms, such as fungi and bacteria. The plant is selected from plants which produce amphiphilic cations such as isoquinolines, e.g., berberine and protoberberinium alkaloids. The present invention also provides flavolignans and porphyrin derivative compounds which have been identified by the method of the present invention as being MDR pump inhibitors.</p> |
