发明名称 |
PROCESS FOR THE IMPROVEMENT OF SPERMATOZOA FERTILIZATION ACTIVITY |
摘要 |
The invention relates to a process for the improvement of spermatozoa fertilization activity, in particular for the increase of spermatozoa motili ty by inhibiting the enzyme phosphatidylinositol-3 kinase (PI3K). The invention further relates to uses and methods of PI3K inhibitors in infertility and assisted reproduction techniques (ART) as well as to a medium for storage and/or transportation of spermatozoa comprising PI3K inhibitors. The PI3K inhibitors are selected from the group consisting of 2-(4-morpholinyl)-8- phenyl-4H-1-benzopyran-4-one (LY294002), wortmannin, quercetin, and derivatives and analogues thereof.
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申请公布号 |
CA2378650(A1) |
申请公布日期 |
2001.02.01 |
申请号 |
CA20002378650 |
申请日期 |
2000.07.25 |
申请人 |
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. |
发明人 |
LUCONI, MICHAELA;BALDI, ELISABETTA;FORTI, GIANNI |
分类号 |
A01K67/02;A61K31/00;A61K31/352;A61K31/366;A61K31/5377;A61K31/585;A61K45/00;A61P15/08;C07D311/22;C12N5/06;(IPC1-7):A61K31/00;B03B7/00;A61D19/00;B01D21/00;B01D43/00;A61D19/02;A01N1/02;A61K31/37;A61K35/52;A61K31/537 |
主分类号 |
A01K67/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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