发明名称 COMPOSTOS COM ACTIVIDADE ANTI-INFLAMATORIA E IMUNOSSUPRESSORA
摘要 Amide compounds of formula (I) are new. R' = H or 1-4C alkyl; A = adamantyl or a mono-, bi-or tri-cyclic radial optionally partially or totally unsaturated, which can contain one or more heteroatoms selected from N,S and O and optionally substituted by OH, alkanoyloxy, primary, secondary or tertiary amino, 1-4C amino alkyl, mono-or di- (1-4C alkyl) amino (1-4C alkyl) halogen, 1-4C alkyl or ti (1-4C alkyl) ammonium (1-4C alkyl); Z = a 1-5C carbon chain optionally containing a double bond or an NR' group; R = H or phenyl; X = O or NR' or is absent; r, m =0-2; B = phenylene or cyclohexylene; Y = OH or amino (1-4C alkyl) optionally interrupted by O; with the proviso that A is fluorenyl only when at the same X is not O and Y is not OH, unless the fluorenyl group is substituted by a tri (1-4C alkyl) ammonium (1-4C alkyl) group.
申请公布号 PT901465(E) 申请公布日期 2001.01.31
申请号 PT19970923053T 申请日期 1997.05.12
申请人 ITALFARMACO S.P.A. 发明人 JACQUES MIZRAHI;FLAVIO LEONI;GIANFRANCO PAVICH;PAOLO MASCAGNI;GIORGIO OBERTOLINI;MAURO BIFFI
分类号 C07D217/02;A61K31/00;A61K31/16;A61K31/47;A61K31/472;A61P29/00;A61P37/00;A61P37/06;C07C243/24;C07C243/38;C07C259/06;C07C259/08;C07C259/10;C07C275/42;C07D217/04;C07D217/16;C07D217/24;(IPC1-7):C07C259/10 主分类号 C07D217/02
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