| 摘要 |
PROBLEM TO BE SOLVED: To obtain an optically active 4-hydroxy-2,6,6-trimethyl-2-cyclohexen-1- one useful as an intermediate for phytohormones, or the like, in high yield by reacting (±)-4-hydroxy-trimethyl-cyclohexen-1-one with a chloroacetic acid ester in the presence of an enzyme and solvolyzing the reaction product. SOLUTION: The objective optically active compound of formula III useful as a synthetic intermediate for optically active abscisic acid known as a phytohormone and zeaxanthin belonging to a carotenoid is produced in high yield and optical purity by reacting (±)-4-hydroxy-2,6,6-trimethyl-2-cyclohexen-1-one of formula I with a chloroacetic acid ester in the presence of an enzyme having asymmetrically acylating activity such as a lipase produced by microorganism belonging to the genus Pseudomonas and solvolyzing the obtained optically active 4-oxo-3,5,5-trimethyl-2-cyclohexenyl chloroacetate of formula II (* shows an asymmetric carbon atom). |
