| 发明名称 |
CONJUGATES OF SODIUM CHANNEL BLOCKERS AND METHODS OF USING THE SAME |
| 摘要 |
Compounds of the general formula P1-L-P2; wherein "P1" is a pyrazinoylguanidine sodium channel blocker, "L" is a linking group, and "P2" is either (i) a pyrazinoylguanidine sodium channel blocker or (ii) a P2Y2 receptor agonist, are disclosed. Pharmaceutical formulations containing the same and methods of use thereof to hydrate mucosal surfaces such as airway mucosal surfaces are also disclosed. |
| 申请公布号 |
CA2378181(A1) |
申请公布日期 |
2001.01.25 |
| 申请号 |
CA20002378181 |
申请日期 |
2000.07.19 |
| 申请人 |
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL |
发明人 |
BOUCHER, RICHARD C., JR. |
| 分类号 |
C07D241/32;A61K;A61K31/495;A61K31/4965;A61K31/70;A61P;A61P1/04;A61P11/00;A61P11/12;A61P43/00;C07D;C07D241/26;C07D401/12;C07H;C07H19/10;C07H19/207 |
主分类号 |
C07D241/32 |
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