METHOD FOR PRODUCING POWDERY PARTICLE-REDUCED FORMULATIONS WITH THE AID OF COMPRESSED GASES

摘要

The invention relates to the production of powdery particle-reduced formulations with the aid of compressed gases. The inventive method is characterized in that: the solid compound to be formulated, said compound consisting of a poorly soluble and mostly bioactive substance, is homogeneously comminuted together with 10-99 wt. % (with regard to the formulation) of a supporting material, which is essentially soluble in the compressed gas mixture, in an agitated autoclave provided with a mechanical comminution device in the presence of compressed gas or mixtures thereof, at method temperatures ranging from 10 to 200 DEG C, and under method pressures ranging from 5 to 500 bar, and, in a second method step; the compressed gas mixture, consisting mostly of dimethyl ether, pure propane and/or carbon dioxide, is expanded by lowering the pressure and is separated away from the homogenate that can also be provided in the form of a molten material. Finally, the powdery particle-reduced formulation is obtained from the resulting homogenate and exhibits significant improvements with regard to solubility properties and especially with regard to the biological availability of compounds which, initially, are poorly soluble or insoluble.