PROCESS FOR OBTAINING 17 beta -(N-TERC-BUTYLCARBAMOYL)-3-ONE-4-AZA-STEROIDS

摘要

17 beta -(N-terc-butylcarbamoyl)-3-one-4-aza-steroids (I) can be obtained by a process which comprises the reaction of 17 beta -(alcoxycarbonyl)-3-one-4-aza-steroid with terc-butylamide of lithium in an organic solvent. Some compounds of formula (I), for example finasteride, are useful as inhibitors of 5- alpha -reductase and can be used in the treatment of benign prostatic hyperplasia and alopecia.