FUSION PEPTIDES COMPRISING A PEPTIDE LIGAND DOMAIN AND A MULTIMERIZATION DOMAIN

摘要

The invention provides novel hybrid molecules comprising a peptide ligand domain which functions to bind a predetermined target molecule and a multimerization domain such as an immunoglobulin constant region domain or a leucine zipper. The hybrid molecules optionally include an additional functional moiety such as an enzyme moiety or a cytotoxic moiety. In preferred embodiments, the hybrid molecules have improved pharmacokinetic or pharmacological properties. The invention further provides for the research, diagnostic and therapeutic use of the hybrid molecules and includes compositions such as pharmaceutical compositions comprising the hybrid molecules.